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The present investigation is concerned with chemical agents which are effective in modifying the behavior and function of the central nervous system.
1 - It is proposed to study a variety of known drugs in this pharmacological class that are in present day use and to synthesize new chemical agents or to modify existing ones as occasion may demand.
2 - The various chemical agents investigated or synthesized will be tested on animals to determine their acute and chronic toxicity. Their pharmacological effects will be studied by a variety of assay technics, such as blood pressure determinations, bronchial dilation recordings, endocrine effects, etc. Complete animal facilities will be maintained for this purpose and pathologic study will be carried out on the affected organs when the animals are sacrificed.
3 - Preliminary clinical investigation will be carried out on the more promising chemical agents, and appropriate laboratory procedures will be performed, such as blood counts, uninalysis, etc. to determine the effectiveness and the side reactions of the drugs under investigation.
4 - Adequate reports will be submitted of the findings at quarterly intervals.
5 - Proposed budget:
Personnel
Synthetic organic chemist..................$7,500.00
Research medical associate.................$6,500.00
Pharmacological assistant..................$5,500.00
Chemical assistant.........................$4,000.00
Histology technician.......................$2,400.00
Clinical technician........................$3,600.00
Chemical consultant........................$1,200.00
Total salaries for personnel..............$30,700.00
Other Expenditures
Animals, animal maintenance & facilities...$4,000.00
Chemical & laboratory supplies, expendable $4,000.00
Miscellaneous permanent equipment..........$2,000.00
Travel, medical meetings, etc..............$2,000.00
Total other expenditures..................$12,000.00
TOTAL.....................................$42,700.00
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